Born in Ecuador and now based in Miami, designer Ximena Kavalekas (you pronounce it hee-men-ah) specializes in python accessories—all handmade in Italy, where she grew up. Simplified shapes (including envelope clutches and lady bags) provide the perfect canvas to flaunt the beauty of her skins, which are treated with vitamins to make them especially soft and light. Our pick? The Carmen. Wear it as a belt bag while the trend is hot—and a crossbody or clutch when it’s not (all her pieces come with cross body straps for versatility).